Comparison of biomarkers performance from Urine and Serum for the early diagnosis of ovarian cancer
نویسندگان
چکیده
This paper compares of biomarker combinations performance extracted from urine and serum samples for the early diagnosis of ovarian cancer. The sample consists of 22 benign and 10 cancer patients. The concentrations of 15 ovarian cancer-specific biomarkers were measured by antibody microbead-assisted multiplexed immunoassay technology. To determine the optimal combination that best distinguish benign from cancer, the AUC of the ROC curve of marker combinations consisting of two biomarkers was estimated. The diagnosis performance was evaluated with Logistic Regression. The highest AUC value of the biomarker combination consisting of two biomarkers was 93.81% and 87.27% for the biomarkers extracted from urine and serum, respectively. This result represents that biomarker combinations extracted from urine has higher performance than those from serum.
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